Rhodium(I)-Catalyzed Regioselective C–H Alkenylation of 2,2′-Bipyridine Derivatives with Alkynes

Abstract In this work, a Rh(I)-catalyzed C3-alkenylation of 2,2′-bipyri­dine-6-carboxamide with terminal and internal alkynes was developed, providing an efficient access to a broad range of alkenylated 2,2′-bipyridine derivatives with exclusive regioselectivity and stereoselectivity. Deuterium labeling experiments indicate that an irreversible rollover C–H activation process is involved in this reaction.