肌红蛋白
一氧化氮
活性氧
生物
癌症
缺氧(环境)
生物化学
细胞生物学
计算生物学
化学
氧气
遗传学
内分泌学
有机化学
作者
Islam Elkholi,Marwa E. Elsherbiny,Marwan Emara
标识
DOI:10.1016/j.bbcan.2022.188706
摘要
Myoglobin (MB) belongs to the well-studied globin proteins superfamily. It has been extensively studied for its physiological roles in oxygen storage and transport for about a century now. However, the last two decades shed the light on unexpected aspects for MB research. Myoglobin has been suggested as a scavenger for nitric oxide and reactive oxygen species (ROS). Furthermore, MB was found to be expressed and regulated in different tissues, beyond the muscle lineage, including cancers. Current evidence suggest that MB is directly regulated by hypoxia and might be contributing to the metabolic rewiring in cancer tissues. In this article, we first discuss the MB physiological roles and then focus on the latter potential roles and regulatory networks of MB in cancer.
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