试剂
烷基化
光催化
化学
反应性(心理学)
光化学
吡啶
氢原子
基质(水族馆)
氧化物
盐(化学)
电子转移
表面改性
组合化学
有机化学
催化作用
烷基
替代医学
物理化学
病理
地质学
海洋学
医学
作者
Łukasz Ciszewski,Dorota Gryko
标识
DOI:10.26434/chemrxiv-2022-j348w
摘要
Pyridine N-oxides only recenly marked their presence in the photocatalysis outbreak, mainly serving as oxypyridinium salt precursors. Herein, their unique reactivity as a hydrogen atom transfer reagent in photochemical, Minisci-type alkylation of electron-deficient heteroarenes is unveiled. The formation of an EDA complex between a heterocyclic substrate and N-oxide precludes the need for a photocatalyst. The developed method allows for a broad range of radical precursors to be used, namely alkanes, alkenes, amides, and ethers, for efficient alkylation of azines.
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