表观遗传学
染色质
生物
遗传(遗传算法)
遗传学
基因
减数分裂
DNA甲基化
后生
计算生物学
进化生物学
基因表达
作者
Wenlong Du,Gaoquan Shi,Chun‐Min Shan,Zhiming Li,Bing Zhu,Songtao Jia,Qing Li,Zhiguo Zhang
标识
DOI:10.1007/s11427-022-2120-1
摘要
Multi-cellular organisms such as humans contain hundreds of cell types that share the same genetic information (DNA sequences), and yet have different cellular traits and functions. While how genetic information is passed through generations has been extensively characterized, it remains largely obscure how epigenetic information encoded by chromatin regulates the passage of certain traits, gene expression states and cell identity during mitotic cell divisions, and even through meiosis. In this review, we will summarize the recent advances on molecular mechanisms of epigenetic inheritance, discuss the potential impacts of epigenetic inheritance during normal development and in some disease conditions, and outline future research directions for this challenging, but exciting field.
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