化学
吡啶
酰胺
键裂
盐酸盐
过氧化氢
组合化学
过渡金属
有机化学
催化作用
作者
Aqin Liu,Yanwu Li,Xiuyu Zhang,Qiulin Kuang,Suzhen Li,Shengjie Liao,Xin Huang,Yin Wang,Ping Xu,Huili Wu,Mei Guo,Wanqian Ma,Yuanlin Song,Xueyuan Hu,Jianyong Yuan
标识
DOI:10.1016/j.tetlet.2022.153967
摘要
This article reports an efficient method for the synthesis of amide derivatives by the direct reactions of aromatic amines with 1,3-diketones promoted by pyridine hydrochloride under metal-free and solvent-free conditions. This transformation was accomplished by cleavage of CC bond in the presence of pyridine hydrochloride as additive, which excludes the use of transition-metals and harsh reaction conditions. This method has a broad substrate scope and good tolerance for sensitive functional groups. A multi-gram scale reaction is also performed to ensure the scalability of the reaction.
科研通智能强力驱动
Strongly Powered by AbleSci AI