光动力疗法
单线态氧
纳米载体
材料科学
自愈水凝胶
肿瘤缺氧
药物输送
光敏剂
氧气
活性氧
化学
纳米技术
光化学
放射治疗
医学
生物化学
有机化学
外科
高分子化学
作者
Mi Zhang,Xiaoguang Liu,Yinghua Mao,Yan He,Juan Xu,Zhenghe Feng,Weilong Tan,Shu Rong,Yonghong Chen,Xuemei Jia,Hong Li
标识
DOI:10.1021/acsami.2c02949
摘要
Hypoxic environment is a bottleneck of photodynamic therapy (PDT) in tumor treatment, as oxygen is the critical substrate for photosensitivity reaction. Herein, a sustained oxygen supply system based on cerium nanoparticles and hydrogel (GHCAC) was explored for enhanced synergistic PDT and gas therapy. Ceria nanoparticles were prepared as a drug carrier by self-assembly mediated by hyaluronic acid (HA), a targeting for CD44 on cervical cancer cells, followed by photosensitizer and l-arginine (l-Arg) loading. Then, the GHCAC system was developed by incorporating a prepared nanocarrier (HCePA) and O2-evolving agent calcium peroxide (CaO2) into the hydrogel (Gel) developed by a poloxamer. Gel in the system could moderately infiltrate H2O to react with CaO2 and generate sustained oxygen using the catalase-like activity of HCePA. The system could efficiently alleviate hypoxia in tumor environments for up to 7 days, meeting the "once injection, repeat irradiation" strategy and enhanced PDT efficacy. Besides, the generated singlet oxygen (1O2) in the PDT process could also oxidize l-Arg into high concentrations of nitric oxide for synergistic gas therapy. The developed oxygen supplied and drug delivery Gel system is a new strategy for synergistic PDT/gas therapy to overcome cervical cancer.
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