海马结构
突触素
海马体
SIRT2
神经科学
突触可塑性
嗅球
神经可塑性
调节器
神经发生
内分泌学
内科学
萧条(经济学)
心理学
生物
中枢神经系统
医学
免疫组织化学
遗传学
锡尔图因
受体
乙酰化
宏观经济学
基因
经济
作者
Kohei Takahashi,Kazuhiro Kurokawa,Hong Liang,Kazuya Miyagawa,Atsumi Mochida-Saito,Hiroshi Takeda,Minoru Tsuji
标识
DOI:10.1016/j.neures.2022.06.001
摘要
Reduced activity of hippocampal silent information regulator protein 2 (SirT2) has been associated with the development of depression caused by disturbances in neuronal and synaptic plasticity. However, changes in the hippocampal SirTs in olfactory bulbectomized (OBX) mice, an animal model of depression, remain unknown. Therefore, this study examined depressive-like behaviors, hippocampal SirTs, synaptic plasticity-associated proteins, and cell proliferation in OBX mice. The OBX mice showed depressive-like behaviors; reduced SirT2, synaptophysin, and PSD95 levels; and reduced cell proliferation in the hippocampus. These data indicate that decreased hippocampal SirT2 may contribute to pathophysiological depression and strongly affect the psychological state.
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