1468 VALUE OF PERINEURAL INVASION, LYMPHOVASCULAR INVASION AND MULTICENTRICITY IN RADICAL PROSTATECTOMY SPECIMENS AS A PREDICTORS OF BIOCHEMICAL RELAPSE IN ORGAN-CONFINED PROSTATE CANCER

You have accessJournal of UrologyProstate Cancer: Localized VII1 Apr 20121468 VALUE OF PERINEURAL INVASION, LYMPHOVASCULAR INVASION AND MULTICENTRICITY IN RADICAL PROSTATECTOMY SPECIMENS AS A PREDICTORS OF BIOCHEMICAL RELAPSE IN ORGAN-CONFINED PROSTATE CANCER Marta Allué, Ángel Borque, Luis M. Esteban, Gerardo Sanz, Jokin Del Amo, Ricardo Ponz, and Juan Morote Marta AlluéMarta Allué Barcelona, Spain , Ángel BorqueÁngel Borque Zaragoza, Spain , Luis M. EstebanLuis M. Esteban Zaragoza, Spain , Gerardo SanzGerardo Sanz Zaragoza, Spain , Jokin Del AmoJokin Del Amo Bilbao, Spain , Ricardo PonzRicardo Ponz Barcelona, Spain , and Juan MoroteJuan Morote Barcelona, Spain View All Author Informationhttps://doi.org/10.1016/j.juro.2012.02.1989AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Different studies have investigated the prognostic utility of perineural invasion, lymphovascular invasion and multicentricity in radical prostatectomy specimens with variable results. The objective of this study is to determine if this histopathological variables in radical prostatectomy specimens could be associated with biochemical relapse in prostate cancer. METHODS A total of 433 patients with clinically localized prostate cancer from 1986 to 2010 were analyzed retrospectively. Whole-mount sections of surgical specimens from all patients who underwent radical prostatectomy were evaluated. The relationship of perineural invasion, lymphovascular invasion and multicentricity with biochemical recurrence were studied with two univariate analisis methods: Kaplan-Meyer analisis (K-M) with log-rank test and Cox regresion model. Multivariate analisis was performed with Cox regression model. RESULTS Perineural invasion was identified in 89.9% of the prostatectomies from patients with biochemical relapse. This percentage was 6.3% for lymphovascular invasion and 57.2% for multicentricity. Univariate analisis showed a significant association between perineural invasion and biochemical relapse under two statistical methods (K-M p<0.001, Hazard ratio (H.R.)=3.6, 95% confidence interval (C.I.) 1.9 to 7.2, p<0.001). Lymphovascular invasion also showed independent association (K-M p<0.001, H.R.=5.8, 95% C.I. 3.1 to 11.1, p<0.001). Multicentricity showed no association in any of the used methods. (K-M p=0.154, H.R.=0.8, 95% C.I. 0.6 to 1.0, p=0.157). On multivariate analysis, the adjustment with the analized variables: age, clinical stage, PSA, PSA density, PSA density of transition zone, prostate and adenoma volume, number of biopsy cores, number and percentage of positive biopsy cores, biopsy and prostate Gleason, biopsy and prostate primary and secondary Gleason, tumoral volume, prostate weigh, patological stage, perineural and linfovascular invasion, multicentricity, oncologic and glandular surgical margins and lymph node, showed that the association with biochemical relapse of perineural invasion (p=0.04) remained (H.R.=2.39, 95% C.I. 1.03 to 5.55) and linfovascular invasion (p=0.07) showed a tendency to significance (H.R.=2.27, 95% C.I. 0.92 to 5.60). CONCLUSIONS Perineural and lymphovascular invasion are independent risk factors of biochemical relapse after radical prostatectomy. Multicentricity is not associated with relapse. © 2012 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 187Issue 4SApril 2012Page: e595-e596 Advertisement Copyright & Permissions© 2012 by American Urological Association Education and Research, Inc.Metrics Author Information Marta Allué Barcelona, Spain More articles by this author Ángel Borque Zaragoza, Spain More articles by this author Luis M. Esteban Zaragoza, Spain More articles by this author Gerardo Sanz Zaragoza, Spain More articles by this author Jokin Del Amo Bilbao, Spain More articles by this author Ricardo Ponz Barcelona, Spain More articles by this author Juan Morote Barcelona, Spain More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...