聚酯纤维
材料科学
聚乳酸
润湿
亲水化
动力学
六甲基二硅氧烷
化学工程
高分子化学
等离子体
复合材料
聚合物
量子力学
物理
工程类
作者
Petr Stloukal,Igor Novák,Matej Mičušík,Michal Procházka,Pavel Kucharczyk,Ivan Chodák,Marián Lehocký,Vladimír Sedlařík
标识
DOI:10.1080/00914037.2017.1309543
摘要
Investigation was made into the effect of plasma treatment on the release kinetics of the drug Temozolomide (TMZ) from thin, biodegradable polyester films, comprising polylactic acid (PLA) and polyester urethane. The authors utilized two systems to achieve this, the first being diffuse coplanar surface barrier discharge, applying air as the gaseous medium, while the other involved capacitively coupled radio frequency discharge plasma under an argon atmosphere with hexamethyldisiloxane. Results showed that both forms of plasma treatment positively reduced the undesirable burst effect and benefited the release rate of TMZ. The hydrolytic degradability of the materials was slightly enhanced following hydrophilization, whereas the same diminished after hydrophobization had taken place. This was especially true for PLA due to modification of its wettability.
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