Comparison of efficacy of intralesional 5-fluorouracil alone versus intralesional triamcinolone acetonide with 5-fluorouracil in small keloids

Objective To evaluate the efficacy of intralesional 5-fluorouracil alone in comparison with the combination of intralesional triamcinolone acetonide and 5-fluorouracil in treatment of small keloids. Methods Sixty patients who fulfilled the inclusion and exclusion criteria were recruited. Patients were randomly divided into two groups. In group A, intralesional 5-fluorouracil 50 mg/ml was used. In group B, combination of triamcinolone acetonide 40mg/dl (0.1ml) and 5-fluorouracil 50mg/ml (0.9ml) was used, on monthly basis for 6 months. Patients were assessed for efficacy, after 6 months of the treatment. Results Efficacy was achieved in 32 cases in which 10 (33.3%) cases were from 5-FU group and 22 (73.3%) were from 5-FU+steroid group, which was statistically significant ( p =0.002.). Conclusion In the treatment of small keloids the combination of 5-FU + steroid has better efficacy in comparison with 5-FU alone.