运行x1
髓样
白血病
慢性粒单核细胞白血病
髓系白血病
生物
骨髓增生异常综合症
血小板紊乱
造血
癌症研究
免疫学
遗传学
干细胞
骨髓
血小板
作者
Raman Sood,Yasuhiko Kamikubo,Paul P. Liu
出处
期刊:Blood
[American Society of Hematology]
日期:2017-04-13
卷期号:129 (15): 2070-2082
被引量:307
标识
DOI:10.1182/blood-2016-10-687830
摘要
Abstract RUNX1 is a member of the core-binding factor family of transcription factors and is indispensable for the establishment of definitive hematopoiesis in vertebrates. RUNX1 is one of the most frequently mutated genes in a variety of hematological malignancies. Germ line mutations in RUNX1 cause familial platelet disorder with associated myeloid malignancies. Somatic mutations and chromosomal rearrangements involving RUNX1 are frequently observed in myelodysplastic syndrome and leukemias of myeloid and lymphoid lineages, that is, acute myeloid leukemia, acute lymphoblastic leukemia, and chronic myelomonocytic leukemia. More recent studies suggest that the wild-type RUNX1 is required for growth and survival of certain types of leukemia cells. The purpose of this review is to discuss the current status of our understanding about the role of RUNX1 in hematological malignancies.
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