生物高聚物
焦磷酸盐
壳聚糖
化学
自愈水凝胶
致电离效应
化学工程
离子键合
生物相容性
分子
圆二色性
离子
结晶学
高分子化学
有机化学
聚合物
生物化学
NMDA受体
受体
工程类
酶
作者
Pasquale Sacco,Sergio Paoletti,Michela Cok,Fioretta Asaro,Michela Abrami,Mario Grassi,Ivan Donati
标识
DOI:10.1016/j.ijbiomac.2016.07.056
摘要
Ionotropic gelation of chitosan by means of opposite charged ions represents an efficient alternative to covalent reticulation because of milder condition of use and, in general, higher biocompatibility of the resulting systems. In this work 90° light scattering (turbidimetry), circular dichroism (CD) and 1H NMR measurements have been performed to study the interactions between the biopolymer and ionic cross-linkers tripolyphosphate (TPP) and pyrophosphate (PPi) in dilute solutions. Thereafter, a dialysis-based technique was exploited to fabricate tridimensional chitosan hydrogels based on both polyanions. Resulting matrices showed a different mechanical behavior because of their peculiar mesh-texture at micro/nano-scale: in the present contribution we demonstrate that TPP and PPi favor the formation of homogeneous and inhomogeneous systems, respectively. The different texture of networks could be exploited in future for the preparation of systems for the controlled release of molecules.
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