化学
亲核细胞
酰化
吡啶
有机化学
药物化学
催化作用
亲核取代
缩合反应
作者
Atsushi Umehara,Hirofumi Ueda,Hidetoshi Tokuyama
标识
DOI:10.1021/acs.joc.6b02097
摘要
A novel condensation reaction of carboxylic acids with various non-nucleophilic N-heterocycles and anilides was developed. The reaction proceeds in the presence of di-tert-butyl dicarbonate (Boc2O), catalytic 4-(dimethylamino)pyridine (DMAP), and 2,6-lutidine and is applicable to the acylation of a wide range of non-nucleophilic nitrogen compounds, including indoles, pyrroles, pyrazole, carbazole, lactams, oxazolidinones, and anilides with high functional group compatibility. The scope of indoles, carboxylic acids, and anilides was also studied.
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