兴奋剂
多巴胺
化学
κ-阿片受体
阿片受体
(+)-纳洛酮
类阿片
药理学
再摄取
受体
内源性激动剂
内分泌学
内科学
多巴胺受体D1
生物
生物化学
医学
血清素
作者
Nuannoi Chudapongse,Seong‐Youl Kim,Robert Krämer,Ing K. Ho
摘要
kappa-Opioid receptor agonists decrease the levels of extracellular dopamine in vivo and in vitro. However, the mechanism(s) underlying these actions are unclear. The objective of this study was to distinguish between an effect of the selective kappa-opioid receptor agonist U-50,488H ((trans-(+/-)-3,4-dichloro-N-methyl-N-(2-[1-pyrrolidinyl]cyclohexyl)benzeneacetamide methanesulfonate) on secretion and reuptake of dopamine by PC12 cells. The data show that U-50,488H has both a modest effect to increase dopamine release and a more pronounced effect to inhibit dopamine uptake. Neither effect was sensitive to nor-binaltorphimine or naloxone, suggesting that they are not mediated through an opioid receptor.
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