化学
保护组
核苷酸
核苷
核酸
群(周期表)
基础(拓扑)
有机化学
立体化学
组合化学
生物化学
数学
基因
数学分析
烷基
摘要
tert-Butyldimethylsilyl chloride reacts selectively with hydroxyl groups in nucleosides and preferentially with the 5′-hydroxyl of deoxynucleosides. The tert-butyldimethylsilyl group can be removed under conditions which do not affect other commonly used acid or base labile protecting groups, yet it is stable to phosphorylation conditions. This allows for the synthesis of a variety of protected deoxynucleosides in good yields and introduces a versatile new protecting group to the nucleoside and nucleotide field.
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