Local Degranulation of Individual Rat Peritoneal Mast Cells Induced by Compound 48/80

Abstract D iamant , B., P. G. K rüger and B. U vnäs . Local degranulation of individual rat peritoneal mast cells induced by compound 48/80 . Acta physiol. scand. 1970. 79 . 1–5. Degranulation of individual rat mast cells is shown to occur at the site of administration of compound 48/80 by the use of micropipets placed close to the mast cell membrane. Varying degree of degranulation can be induced. It is possible to induce repeated degranulation by local application of 48/80 to the same area of the cell at least four times. The results suggest that compound 48/80 acts directly on the cell membrane and this interaction seems to be the primary cause of the extrusion of granules.