水通道蛋白4
星形胶质细胞
水通道蛋白
平衡
室管膜细胞
水运
神经科学
细胞生物学
下丘脑
生物
化学
中枢神经系统
水流
生物化学
环境工程
工程类
作者
Christine Iacovetta,Elke Rudloff,Rebecca Kirby
标识
DOI:10.1111/j.1939-165x.2011.00390.x
摘要
Abstract: Emerging evidence suggests that aquaporin ( AQP ) 4 water channels play an important role in water homeostasis in the brain. These water channels are most abundant in the cell membrane of astrocytes, but are also present within ependymal cell membranes and in osmosensory areas of the hypothalamus. Water transport through AQP 4 depends on concentration gradients across the membrane, but the rate of transport is determined by the capacity of astrocytes to up‐ and down‐regulate AQP 4 numbers, their location within the membrane, and the overall permeability of the channel. Other functions of brain AQP 4 involve potassium uptake and release by astrocytes, migration of glial cells, glial scarring, and astrocyte‐to‐astrocyte cell communication. AQP water channels are involved in formation and control of edema in the brain and in multiple disease processes in the brain, such as seizures and tumors. There is abundant scientific literature on AQP 4 describing its structure, function, location, and role in water homeostasis and edema in the brain. Investigation of AQP expression in the canine and feline brain should be pursued so that clinically relevant comparisons between findings in mice, rats, and people and animal patients can be made.
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