自噬
乙酰化
细胞生物学
组蛋白
表观遗传学
甲基化
机制(生物学)
生物
DNA甲基化
遗传学
基因
基因表达
细胞凋亡
认识论
哲学
作者
Minsol Jeon,Jisu Park,Eunbi Yang,Hee‐ji Baek,Hyun-Kyung Kim
摘要
Autophagy is a highly conserved mechanism responsible for cellular homeostasis and integrity in a variety of physiological conditions. Materials targeted for degradation are directed to autophagosomes and autolysosomes, where they are broken down into their base components. Aberrant regulation of autophagy is significantly associated with various cancers and neurodegenerative diseases. Recently, accumulating evidence has revealed that the coordinated regulation of histone and non-histone protein modification is associated with autophagy. In this review, we highlight the recent progress that has been made in elucidating the molecular basis of protein methylation and acetylation associated with autophagy at the transcriptional and posttranslational levels. Furthermore, we discuss the importance of describing causality between protein methylation/acetylation and autophagy regulation as compelling therapeutic opportunities in cancer pathogenesis and progression.
科研通智能强力驱动
Strongly Powered by AbleSci AI