机械转化
软骨细胞
细胞生物学
线粒体
生物
安普克
骨关节炎
软骨
细胞内
细胞外
神经科学
医学
蛋白激酶A
解剖
激酶
病理
替代医学
作者
Weizhou Jiang,Huan Liu,Rongxue Wan,Yanjiao Wu,Zhanjun Shi,Wenhua Huang
标识
DOI:10.1016/j.arr.2021.101315
摘要
Mechanical loading is essential for chondrocyte health. Chondrocytes can sense and respond to various extracellular mechanical signals through an integrated set of mechanisms. Recently, it has been found that mitochondria, acting as critical mechanotransducers, are at the intersection between extracellular mechanical signals and chondrocyte biology. Much attention has been focused on identifying how mechanical loading-induced mitochondrial dysfunction contributes to the pathogenesis of osteoarthritis. In contrast, little is known regarding the mechanisms underlying functional alterations in mitochondria induced by mechanical stimulation. In this review, we describe how chondrocytes perceive environmental mechanical signals. We discuss how mechanical load induces mitochondrial functional alterations and highlight the major unanswered questions in this field. We speculate that AMP-activated protein kinase (AMPK), a master regulator of energy homeostasis, may play an important role in coupling force transmission to mitochondrial health and intracellular biological responses.
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