黑色素瘤
医学
癌变
信号转导
癌症研究
恶性转化
发病机制
皮肤癌
癌症
生物信息学
免疫学
遗传学
生物
内科学
作者
Lillian Sun,Joshua Arbesman
标识
DOI:10.1016/j.cps.2021.05.002
摘要
Melanoma is the most lethal type of skin cancer, originating from the uncontrolled proliferation of melanocytes. The transformation of normal melanocytes into malignant tumor cells has been a focus of research seeking to better understand melanoma’s pathogenesis and develop new therapeutic targets. Over the past few decades, a conglomeration of studies has pinpointed several driver mutations and their associated signaling pathways. In this review, we summarize the key signaling pathways and the driver mutations involved in melanoma tumorigenesis and also discuss the potential underlying mechanisms.
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