Gamma rhythm communication between entorhinal cortex and dentate gyrus neuronal assemblies

Brain region coordination in learning Gamma-frequency oscillations have been hypothesized as a physiological mechanism of interregional communication in the brain. However, until now, all supporting data have been correlational and thus indirect. Fernández-Ruiz et al. examined gamma-frequency activity and spike coupling between the entorhinal cortex and hippocampal dentate gyrus during learning and after selective perturbation of gamma-frequency spike timing. They observed an integrated neuron, gamma-band, and task-specific organization of the entorhinal cortex–hippocampal circuits. These data demonstrate that specific, projected gamma-frequency oscillation patterns dynamically engage functionally related cell assemblies across brain regions in a task-specific manner. Science , this issue p. eabf3119