光热治疗
光动力疗法
抗菌活性
材料科学
阳离子聚合
纳米颗粒
致病菌
纳米技术
广谱
组合化学
化学
细菌
化学工程
有机化学
高分子化学
工程类
生物
遗传学
作者
Bei Liu,Yafang Liu,Jinglei Qin,Hongshang Peng
出处
期刊:ChemNanoMat
[Wiley]
日期:2021-11-23
卷期号:8 (1)
被引量:1
标识
DOI:10.1002/cnma.202100357
摘要
Abstract Considering the implications of inherent resistance of pathogenic bacteria, it is important to design a new generation of nonchemotherapic nanoagents for effective antibacterial therapy. Herein, we illustrate a one‐step reprecipitation‐encapsulation strategy to incorporate hydrophobic photosensitizers (ZnPc) and photothemal agents (dopamine hydrochloride) with a cationic poly‐L‐lysine (PLL) layer. Upon light irradiation, the polymeric nanohybrid exhibits high photo‐to‐thermal conversion efficiency (30.3%) and effective 1 O 2 generation capability. To further enhance the antibacterial efficiency, Ag nanoparticle, a typical broad‐spectrum antibacterial agent, was decorated on the surface of PLL layer by in‐situ reduction. The as‐synthesized nanohybrids, referred to as ZnPc/DA@Ag, achieved a robust photodynamic/photothermal/Ag antibacterial capability without apparent systemic toxicity, thus holding great potential for broad‐spectrum eradication of pathogenic bacteria.
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