多巴胺
神经科学
内嗅皮质
被盖腹侧区
光遗传学
内容寻址存储器
联想学习
海马结构
海马体
纹状体
编码(内存)
计算机科学
生物
心理学
多巴胺能
人工智能
人工神经网络
作者
Jason Y. Lee,Heechul Jun,Shogo Soma,Tomoaki Nakazono,Kaori Shiraiwa,Ananya Dasgupta,Taro Nakagawa,Jiayun Xie,Jasmine Chavez,Rodrigo Romo,Sandra Yungblut,Meiko Hagihara,Katsumi Murata,Ken Igarashi
出处
期刊:Nature
[Springer Nature]
日期:2021-09-22
卷期号:598 (7880): 321-326
被引量:34
标识
DOI:10.1038/s41586-021-03948-8
摘要
Mounting evidence shows that dopamine in the striatum is critically involved in reward-based reinforcement learning1,2. However, it remains unclear how dopamine reward signals influence the entorhinal-hippocampal circuit, another brain network that is crucial for learning and memory3-5. Here, using cell-type-specific electrophysiological recording6, we show that dopamine signals from the ventral tegmental area and substantia nigra control the encoding of cue-reward association rules in layer 2a fan cells of the lateral entorhinal cortex (LEC). When mice learned novel olfactory cue-reward associations using a pre-learned association rule, spike representations of LEC fan cells grouped newly learned rewarded cues with a pre-learned rewarded cue, but separated them from a pre-learned unrewarded cue. Optogenetic inhibition of fan cells impaired the learning of new associations while sparing the retrieval of pre-learned memory. Using fibre photometry, we found that dopamine sends novelty-induced reward expectation signals to the LEC. Inhibition of LEC dopamine signals disrupted the associative encoding of fan cells and impaired learning performance. These results suggest that LEC fan cells represent a cognitive map of abstract task rules, and that LEC dopamine facilitates the incorporation of new memories into this map.
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