The correlation of blood pressure variability and cognitive function in hypertension patients: A meta‐analysis

Cognitive impairment (CI) is very common in patients with hypertension. It is necessary to conduct a meta-analysis to evaluate the association between cognitive function and blood pressure variability in patients with hypertension, to provide insights into the clinical management of hypertension and cognitive impairment.We searched PubMed and other databases for case-control studies on the association between blood pressure variability and cognitive function up to 15 July 2021. Two researchers independently screened the literature and retrieved the data. RevMan 5.3 was used for meta-analysis.A total of 13 studies involving 2754 patients were included. Meta-analysis indicated that 24-hours systolic (MD = 3.54, 95% CI [2.48, 4.60]) and diastolic (MD = 2.43, 95% CI [1.55, 3.31]) blood pressure variation coefficients in the CI group were significantly higher than that of non-CI group (all P < .05). Standard deviations of systolic (MD = 2.20, 95% CI [0.27, 4.13]) and diastolic (MD = 1.79, 95% CI [0.80, 2.79]) blood pressure variation in the CI group were significantly higher than that of the non-CI group (all P < .05). Mean systolic (MD = 3.73, 95% CI [0.92, 6.53]) and diastolic (MD = 5.41, 95% CI [0.42, 10.40]) blood pressure variation in the CI group were significantly higher than that of non-CI group (all P < .05). There were no statistically significant differences in the morning peak systolic (MD = 7.85, 95% CI [-1.30, 17.01]) and diastolic (MD = 4.44, 95% CI [-6.00, 14.89]) blood pressure drop between the CI group and non-CI group (all P > .05).CI in hypertensive patients is closely associated with increased blood pressure variability. Clinical healthcare providers should pay attention to the management of blood pressure variability in hypertensive patients to reduce the occurrence of CI.