支气管肺发育不良
细胞外小泡
小RNA
羊水
医学
胞外囊泡
再生医学
癌症研究
炎症
治疗方法
免疫学
细胞生物学
病理
微泡
化学
生物
干细胞
胎儿
基因
胎龄
生物化学
疾病
怀孕
遗传学
作者
Michael A. Bellio,Karen C. Young,Julian Milberg,Ivan Santos,Zanub Abdullah,Danique Stewart,Alissa Arango,Pingping Chen,Jian Huang,Kevin Williams,Kaitlyn Kelly,Shanique Sterling,Aisha Khan,Xiumin Xu,George C. Shapiro,Maria Ines Mitrani
出处
期刊:Cytotherapy
[Elsevier]
日期:2021-12-01
卷期号:23 (12): 1097-1107
被引量:4
标识
DOI:10.1016/j.jcyt.2021.07.011
摘要
Extracellular vesicles (EVs) are being tested for their use as novel therapeutics. However, the optimal source of EVs is currently under investigation. Amniotic fluid (AF) is a natural source of EVs that can be easily obtained for use in regenerative medicine, yet AF-EV characterization has not been fully explored.Here the authors demonstrate AF as a rich source of EVs and identify the microRNA and proteomic cargo. Bioinformatics analysis of this cargo revealed multiple pathway targets, including immunomodulatory, anti-inflammatory and free radical scavenging networks. The authors further demonstrated the therapeutic potential of this EV product as a novel preventative agent for bronchopulmonary dysplasia (BPD).Intra-tracheal administration of AF-EVs preserved alveolar development, attenuated vascular remodeling and pulmonary hypertension, decreased lung pro-inflammatory cytokine expression and reduced macrophage infiltration in an experimental BPD model.The authors' results suggest that AF is a viable biological fluid for EV harvest and that AF-EVs have strong therapeutic potential for pulmonary diseases, such as BPD, warranting further development to transition this novel EV product into the clinic.
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