模块化(生物学)
控制重构
意识
神经科学
动态功能连接
清醒
功能磁共振成像
心理学
认知
模块化设计
网络动力学
计算机科学
认知科学
脑电图
生物
嵌入式系统
离散数学
操作系统
遗传学
数学
作者
Haiyang Liu,Ke Hu,Y. Peng,Xiao-Han Tian,Meng Wang,Bo Ma,Yin Wu,Wenyun Sun,Bing Liu,Ang Li,Ruquan Han
标识
DOI:10.1016/j.bbr.2021.113685
摘要
Consciousness is supported by rich neuronal dynamics to orchestrate behaviors and conscious processing can be disrupted by general anesthetics. Previous studies suggested that dynamic reconfiguration of large-scale functional network is critical for learning and higher-order cognitive function. During altered states of consciousness, how brain functional networks are dynamically changed and reconfigured at the whole-brain level is still unclear. To fill this gap, using multilayer network approach and functional magnetic resonance imaging (fMRI) data of 21 healthy subjects, we investigated the dynamic network reconfiguration in three different states of consciousness: wakefulness, dexmedetomidine-induced sedation, and recovery. Applying time-varying community detection algorithm, we constructed multilayer modularity networks to track and quantify dynamic interactions among brain areas that span time and space. We compared four high-level network features (i.e., switching, promiscuity, integration, and recruitment) derived from multilayer modularity across the three conditions. We found that sedation state is primarily characterized by increased switching rates as well as decreased integration, representing a whole-brain pattern with higher modular dynamics and more fragmented communication; such alteration can be mostly reversed after the recovery of consciousness. Thus, our work can provide additional insights to understand the modular network reconfiguration across different states of consciousness and may provide some clinical implications for disorders of consciousness.
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