Guide to the Expression of Uncertainty of Measurement: Point/Counterpoint

With great interest I read the “Point/Counterpoint” articles by Drs. Krouwer (1) and Kristiansen(2). In this regard, I would like to raise three issues: two analytical and one clinical. With respect to the first analytical issue: laboratory experts and external quality assurance system organizers advocate that laboratory measurements be highly accurate, i.e., unbiased and precise. Although manufacturers of routine measurement procedures are usually able to solve most of the problems of imprecision, they are often unable to solve problems related to measurement bias. In my opinion, these Point/Counterpoint articles put undue pressure on the manufacturers to “improve the quality of their products”. The professionals in laboratory medicine should provide guidance to the manufacturers to help solve the problems of accuracy in a fair and transparent manner. Quantities measured or determined in laboratory medicine are now divided into two categories: (A) those …