肿瘤微环境
PI3K/AKT/mTOR通路
缺氧诱导因子
肿瘤进展
转录因子
缺氧(环境)
癌症研究
HIF1A型
肿瘤缺氧
血管生成
癌症
生物
癌细胞
化学
细胞生物学
免疫学
信号转导
医学
肿瘤细胞
内科学
氧气
基因
生物化学
放射治疗
有机化学
作者
Saurabh Satija,Harpreet Kaur,Murtaza M. Tambuwala,Prabal Sharma,Manish Vyas,Navneet Khurana,Neha Sharma,Hamid A. Bakshi,Nitin B. Charbe,Flavia C. Zacconi,Alaa A. A. Aljabali,Srinivas Nammi,Harish Dureja,Thakur Gurjeet Singh,Gaurav Gupta,Daljeet Singh Dhanjal,Kamal Dua,Dinesh Kumar Chellappan,Meenu Mehta
出处
期刊:Current Molecular Pharmacology
[Bentham Science]
日期:2021-08-16
卷期号:14 (3): 321-332
被引量:22
标识
DOI:10.2174/1874467214666210120154929
摘要
Hypoxia is an integral part of the tumor microenvironment, caused primarily due to rapidly multiplying tumor cells and a lack of proper blood supply. Among the major hypoxic pathways, HIF-1 transcription factor activation is one of the widely investigated pathways in the hypoxic tumor microenvironment (TME). HIF-1 is known to activate several adaptive reactions in response to oxygen deficiency in tumor cells. HIF-1 has two subunits, HIF-1β (constitutive) and HIF-1α (inducible). The HIF-1α expression is largely regulated via various cytokines (through PI3K-ACT-mTOR signals), which involves the cascading of several growth factors and oncogenic cascades. These events lead to the loss of cellular tumor suppressant activity through changes in the level of oxygen via oxygen-dependent and oxygen-independent pathways. The significant and crucial role of HIF in cancer progression and its underlying mechanisms have gained much attention lately among the translational researchers in the fields of cancer and biological sciences, which have enabled them to correlate these mechanisms with various other disease modalities. In the present review, we have summarized the key findings related to the role of HIF in the progression of tumors.
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