纳米技术
DNA
纳米结构
材料科学
DNA折纸
纳米材料
DNA纳米技术
癌症治疗
体内
癌症
化学
遗传学
生物
生物化学
作者
Yun Zeng,Rachel Nixon,Wenyan Liu,Risheng Wang
出处
期刊:Biomaterials
[Elsevier]
日期:2021-01-01
卷期号:268: 120560-120560
被引量:30
标识
DOI:10.1016/j.biomaterials.2020.120560
摘要
Deoxyribonucleic acid (DNA) is a molecular carrier of genetic information that can be fabricated into functional nanomaterials in biochemistry and engineering fields. Those DNA nanostructures, synthesized via Watson-Crick base pairing, show a wide range of attributes along with excellent applicability, precise programmability, and extremely low cytotoxicity in vitro and in vivo. In this review, the applications of functionalized DNA nanostructures in bioimaging and tumor therapy are summarized. We focused on approaches involving DNA origami nanostructures due to their widespread use in previous and current reports. Non-DNA origami nanostructures such as DNA tetrahedrons are also covered. Finally, the remaining challenges and perspectives regarding DNA nanostructures in the biomedical arena are discussed.
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