抗真菌
抗血栓
吲哚生物碱
吲哚试验
化学
药理学
作用机理
生物
立体化学
医学
微生物学
生物化学
体外
心脏病学
作者
Faheem Faheem,Banoth Karan Kumar,Kondapalli Venkata Gowri Chandra Sekhar,Selvaraj Kunjiappan,Joazaizulfazli Jamalis,Rafael Balaña‐Fouce,Sankaranarayanan Murugesan
标识
DOI:10.2174/1389557520666201001130114
摘要
β-Carboline, a naturally occurring indole alkaloid, holds a momentous spot in the field of medicinal chemistry due to its myriad of pharmacological actions like anticancer, antiviral, antibacterial, antifungal, antileishmanial, antimalarial, neuropharmacological, anti-inflammatory and antithrombotic among others. β-Carbolines exhibit their pharmacological activity via diverse mechanisms. This review provides a recent update (2015-2020) on the anti-infective potential of natural and synthetic β-carboline analogs focusing on its antibacterial, antifungal, antiviral, antimalarial, antileishmanial and antitrypanosomal properties. In cases where enough details are available, a note on its mechanism of action is also added.
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