Spontaneous Regression of High-Grade B-Cell Lymphoma With MYC and BCL2 Rearrangements: Case Report and Literature Review

High-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements (double-hit or triple-hit lymphoma) was introduced in the 2016 revision of the World Health Organization classification of lymphomas as a separate entity.1 These mature B-cell lymphomas are considered highly aggressive, with most patients presenting with advanced clinical stage disease (III/IV). Primary refractory disease following immunochemotherapy is common.2 Most patients are elderly, with a median age at diagnosis in the sixth to seventh decade, with only occasional reports of cases in young individuals.