纳米医学
细胞外小泡
微泡
再生(生物学)
癌症治疗
生物相容性
材料科学
纳米技术
细胞生物学
纳米颗粒
计算生物学
小RNA
医学
癌症
生物
基因
内科学
冶金
生物化学
作者
Peipei Wu,Bin Zhang,Dickson Kofi Wiredu Ocansey,Wenrong Xu,Hui Qian
出处
期刊:Biomaterials
[Elsevier]
日期:2021-02-01
卷期号:269: 120467-120467
被引量:187
标识
DOI:10.1016/j.biomaterials.2020.120467
摘要
Extracellular vesicles (EVs) have unique structural, compositional, and morphological characteristics as well as predominant physiochemical stability and biocompatibility properties. They play a crucial role in pathophysiological regulation, and also have broad prospects for clinical application in the diagnosis, prognosis, and therapy of disease, and tissue regeneration and repair. Herein, the biosynthesis and physiological functions and current methods for separation and identification of EVs are summarized. Specifically, engineered EVs may be used to enhance targeted therapy in cancer and repair damaged tissues, and they may be developed as an individualized imaging diagnostic reagent, among other potential applications. We will focus on reviewing recent studies on engineered EVs in which alterations enhanced their therapeutic capability or diagnostic imaging potential via physical, chemical, and biological modification approaches. This review will clarify the superior biological functions and powerful therapeutic potential of EVs, particularly with regard to new designs based on EVs and their utilization in a new generation of nanomedicine diagnosis and treatment platforms.
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