汤剂
尼氏体
医学
周围神经病变
背
外围设备
神经病理性疼痛
奥沙利铂
神经毒性
内科学
药理学
内分泌学
解剖
染色
病理
毒性
癌症
糖尿病
结直肠癌
作者
Rong Ding,Yue Wang,Ji-Xiao Zhu,Wei Lu,Guoli Wei,Zhancheng Gu,Zhentao An,Jiege Huo
标识
DOI:10.31083/j.jin.2020.04.1154
摘要
The effects of Danggui Sini decoction on peripheral neuropathy in oxaliplatin-induced peripheral is established. The results indicated that Danggui Sini decoction treatment significantly reduced the current amplitude of dorsal root ganglia cells undergoing agonists stimuli compared to the model-dorsal root ganglia group (P < 0.05). Danggui Sini decoction treatment significantly inhibited the inflammatory response of dorsal root ganglia cells compared to the model-dorsal root ganglia group (P < 0.05). Danggui Sini decoction treatment significantly enhanced the amounts of Nissl bodies in dorsal root ganglia cells compared to the Model-dorsal root ganglia group (P < 0.05). Danggui Sini decoction treatment improved ultra-microstructures of dorsal root ganglia cells. In conclusion, Danggui Sini decoction protected against neurotoxicity of oxaliplatin-induced peripheral neuropathy in rats by suppressing inflammatory lesions, improving ultra-microstructures, and enhancing amounts of Nissl bodies.
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