尼奥体
Zeta电位
傅里叶变换红外光谱
差示扫描量热法
化学
抗氧化剂
乳状液
色谱法
材料科学
纳米颗粒
化学工程
纳米技术
小泡
生物化学
膜
工程类
物理
热力学
作者
Le Huy Trinh,Alireza Takzare,Dlzar D. Ghafoor,Ahmed Faisal Siddiqi,Sahithya Ravali,Mohammad Shalbaf,Mahdiyeh Bakhtiar
标识
DOI:10.1016/j.jddst.2019.05.046
摘要
The Trachyspermum copticum essential oil (TCEO) has been incorporated into niosomes (NIO-TCEO). The chemical composition of the TCEO has been evaluated using Gas chromatography mass spectrometry (GC-MS) and the antioxidant activity of the TCEO has been characterized by radical scavenging capacity (RSC). The niosomes have been characterized with respect to their size, zeta potential, morphology, encapsulation efficiency, in vitro release, and cell toxicity against hepatocellular carcinoma cell line (HepG2). The interaction of the TCEO with niosomes has been studied using Fourier transform infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC). Our study has shown an excellent antioxidant activity of the essential oil with IC50 of 18.32 ± 3.6 μg/ml. The size of the niosomes has been around 151.06 ± 5.3 nm and the TCEO entrapment efficiency has been 87.41 ± 5.97%. Our results have demonstrated that niosomes loaded with TCEO have a potential application for cancer therapy.
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