医学
失眠症
替代医学
随机对照试验
科学证据
人口
安眠药
睡眠障碍
重症监护医学
临床试验
梅德林
精神科
循证医学
内科学
病理
哲学
认识论
法学
环境卫生
政治学
作者
Bingli Cheng,Yanfei Liu,Jinfan Tian,Rui Gao,Yue Liu
出处
期刊:Current Vascular Pharmacology
[Bentham Science]
日期:2020-06-04
卷期号:18 (4): 307-321
被引量:7
标识
DOI:10.2174/1570161117666190506111239
摘要
Insomnia is a widespread sleep disorder in the general population, and it is a risk factor for impaired function, the development of other medical and mental disorders, and causes an increase in health care costs. In view of the health hazards of insomnia and the shortcomings of western medicine, Complementary and Alternative Medicine (CAM) should be considered in the management of insomnia. The present overview reports the potential role of herbal medicine and non-pharmacological therapies in the treatment of insomnia and summarizes the scientific evidence reported from 2008 to 2018. PubMed and Web of Science databases were searched for studies published from 2008 to 2018. 17 randomized controlled trials and 22 non-pharmacological therapies were included in this review, and the results showed that CAM had certain advantages in the treatment of insomnia. The safety of CAM for insomnia was acceptable. Meanwhile, based on pre-clinical trial, the possible mechanisms of CAM for insomnia were modulation of circadian rhythm, GABA receptor activation, antagonisms of 5-HT receptors, inhibition of glutamate-mediated pathways, and attenuation of inflammation. CAM for insomnia has made some progress, but high quality evidence-based medical evidence is still needed to provide guidance for clinical application.
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