Diastereo- and Enantioselective Synthesis of Dimethylcyclohexanamines by Asymmetric Reductive Amination

All articles of this category A series of optically active dimethylcyclohexanamines 6a-c, e , with ee values ranging from 86- >99%, have been synthesized by asymmetric reductive amination of the corresponding racemic diastereomeric cyclohexanones 3a-c, e . Their conformation and configuration are also discussed. asymmetric reductive amination - dimethylcyclohexanamines - diastereo- and enantioselectivity - absolute configuration