A Greener Approach to Prepare Natural Deep Eutectic Solvents

Abstract Natural deep eutectic solvents (NADES) is one of the hottest issues in the field of green chemistry. However, it is possible to make them greener? Herein we propose a new microwave (MW) assisted preparation demanding only seconds. The MW‐NADES were challenged with those obtained by the classical Heating & Stirring procedure in terms of green analytical metrics and physical parameters. Indeed, the following analytical applications were tested: a) extraction media for phenolics and alkaloids from plant, b) enhancers for electrochemical detection of phenolic compounds. Our results demonstrate outstanding environmental advantages as the dramatic decrease of synthesis time (the shortest time to date, 60 minutes to 20 seconds) and energy consumption (650 times lower). The analytical performance and physicochemical parameters were comparable with the traditional NADES.