This chapter contains sections titled: Introduction Septins Interact with other Septins Septins Interact with Actin-Associated Proteins Septin Interaction with Microtubules, and the Microtubule-Associated Protein MAP4 Septin-Binding Partners and Regulation of Secretion Septin-Binding Partners and Neurology Septin-Binding Partners and Infectious Diseases Conclusions Acknowledgements References