Anhydrous and Hydrated Protein Models Derived from High-Resolution and Low-Resolution Techniques

High-resolution crystallography provides information on the precise 3D structure of proteins or other (bio)macromolecules, including ligands and several water molecules. In the case of small proteins, NMR techniques may be equally purposive. Reconstructions from cryo-electron microscopy may also supply precise anhydrous models. The most intimate structural details of proteins can be visualized from application of these high-resolution techniques (Creighton, 2010a, 2010b; Serdyuk et al., 2007).