In recent years,the study about the relationship between Glypican-3(GPC3) and hepatocellular carcinoma(HCC) increased year by year.GPC3 has higher expression in the blood serum and tumor tissues of patients with HCC,and it has higher sensitivity and specificity in the diagnosis of HCC.The expression of GPC-3 also has a certain relationship with the prognosis of HCC.Meanwhile,GPC3 provided a novel for the treatment of HCC.