Dynamic Effect of Heiliangchongji (HLCJ) on Leukopenia and Neutropenia Introduced by Cyclophosphamide in Mice

bjective:To investigate the protective action of HLCJ on the leukopenia and neutropenia induced by cytoxan(CTX)in mice. Method: Models of mice with leukopenia and neutropenia here were made by injecting with CTX(100 mg/kg)for 3 days,meanwhile,these mice were treated with HLCJ and the dynamic changes of 1eukocyte and neutrophil in these mice were observed.Results:HLCJ(32g/kg,16g/kg) administrated for 8 days could improve leukopenia and neutropenia induced by CTX in mice.Oral administration of HLCJ (32g/kg,16g/kg,8g/kg) for l2 days could increase the decreased number 0f 1eukocytes and neutrophil in CTX treated mice. Conclusion: HlCJ has significant protective effect on leukopenia and neutropenia induced by cytoxan in mice.