Objective To explore the clinical effects of free fibular flap transplantation for repair of mandible defect. Methods 90 patients with mandible defect were classified into two groups according to surgical repair methods.48 cases were treated with vascular anastomosis dissociation fibular flap as observation group,other 42 cases were treated with titanium plate fixation as control group,and the therapeutic effect was compared between the two groups.Results The surgery was successful and all cases were discharged within 12 days.The total effective rates of observation group and control group were 97.9% and 85.7%,respectively,and there was statistically significant between the two groups(P0.05).Color doppler examination showed unobstructed blood flow in lower limb vessels 3 weeks after surgery in observation group,all patients walked normally and no one occurred skin flap necrosis in postoperative 3~12 months follow-up.However,3 cases occurred titanium plate loose after operation in control goup.Conclusion Vascular anastomosis fibular flap to repair mandible defect is a reliable,less postoperative complications,better prognosis method,and worthy to be used widely.