Study on Synthesis of 2-Cyano-3-ureidoacrylic Acid Ethyl Ester

2-Cyano-3-ureidoacrylic acid ethyl ester was synthesized from ethyl cyanoacetate,triethyl orthoformate and urea in xylene.The product was purified by recrystallization from ethyl acetate,and the structure was characterized by()～1H NMR.The optimized reaction conditions were:n(ethyl cyanoacetate)∶n(triethyl orthoformate)∶n(urea)=1.0∶1.12∶1.1 and reaction time 10 h.The yield was 73.65%.This route is suitable for industrial production.