Effects of Rosuvastatin and Simvastatin on hs-CRP, IL-6 and Cardiovascular Events in Patients with Acute Coronary Syndrome

Objective To explore the effects of rosuvastatin and simvastatin on hs-CRP, IL-6 and cardiovascular events in patients with acute coronary syndrome(ACS). Methods 80 case of ACS patients were selected and randomLy divided into rosuvastatin group and simvastatin group(40 cases in each group). They were given conventional therapy, rosuvastatin group was given rosuvastatin(10 mg/d), and simvastatin was given simvastatin(20 mg/d) for six months. The levels of hs-CRP, IL-6 were detected, we observed the incidence of cardiovascular events during treatment. Results The levels of hs-CRP, IL-6 decreased significantly(all P0.05) in both groups, while the level of hs-CRP, IL-6 decreased most significantly(P0.05). The incidence of cardiovascular events of rosuvastatin group was lower than simvastatin group, but difference was not significant(P0.05). Conclusion Rosuvastatin and simvastatin can both decrease the levels of hs-CRP, IL-6 in ACS patients, and decrease the incidence of cardiovascular vents. Rosuvastatin is better than simvastatin.