Expression and significance of c-kit in conventional osteosarcoma

Objective:To investigate the expression of c-kit in conventional osteosarcoma and their relationships with clinicopathological parameters and prognostic value.Methods: The expression of c-kit was determined in 40 patients with conventional osteosarcoma by immunohistochemistry.Their relationship with prognosis was statistically analyzed.Results:(1)The expression rate of c-kit in conventional osteosarcoma was 62.5%.(2)The conventional osteosarcoma with a high expression of c-kit was prone to recur locally.(3)The post-operative survival of patients with highly expressed c-kit was significantly lower than that of patients with lowly expressed c-kit.Conclusion: The expression of c-kit is related to the biological behavior of osteosarcoma in conventional osteosarcoma,and it is valuable in judging the prognosis and therapy for osteosarcoma.