Selection for the high and stable lincomycin-producing strain

As an original strain, Lincomycin-producing 82-7 # was multiple mutated through LiCl, EMS and ultraviolet in presence of lincomycin. The high and stable lincomycin-producing strain named as 64-12 # was obtained. It is demonstrated that lincomycin-producing activity of this strain in the shaking flask increases by 25%. With the optimal culture solution, it's activity raises by 28%. Trial-production by 30 tons fermentor indicates that the lincomycin-producing activity of the strain increase 16 8% than that of the original one.