With pomegranate peel as raw material, the extraction of total polyphenols from pomegranate peel was studied. The results showed that material to liquid ratio and temperature had significant effects on extraction yield of total polyphenols, and the optimum extraction conditions were as follows: alcohol concentration 50%, extraction time 90 min, material to liquid ratio 1∶25(g/m L),temperature 60 ℃. Under those conditions, the yield of polyphenols from pomegranate peel was 22.92%.