胺化
化学
药效团
甲酰胺
组合化学
烷基
催化作用
铜
有机化学
立体化学
作者
Qiong Li,Shu‐Yu Zhang,Gang He,Zhaoyan Ai,William A. Nack,G. Chen
出处
期刊:Organic Letters
[American Chemical Society]
日期:2014-03-04
卷期号:16 (6): 1764-1767
被引量:184
摘要
In this report, a highly efficient method for the room temperature installation of alkyl amino motifs onto the ortho position of anilines via Cu-catalyzed carboxamide-directed amination with alkylamines is described. This method offers a practical solution for the rapid synthesis of complex arylamines from simple starting materials and enables new planning strategies for the construction of arylamine-containing pharmacophores. A single electron transfer (SET)-mediated mechanism is proposed.
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