Effects of marrow stroma cells on the expression of nerve growth factor and brain-derived neurotrophic factor after traumatic rat brain injury

Objective:To investigate the effects of marrow stroma cells(MSCs) on the expression of nerve growth factor(NGF) and brain-derived neurotrophic factor(BDNF) after traumatic rat brain injury.Method:Intravenous injection of the MSCs into the rats after their traumatic brain injury.The level of growth factors was measured quantitatively by using enzyme-linked immunosorbent assay(ELISA).Growth factors studied included NGF and BDNF.Result:The MSCs preferentially migrated into the injured hemisphere.NGF and BDNF were expressed in the injured brain of both treated as well as control rats;however,quantitative ELISA studies showed that expression of NGF and BDNF was significantly increased(P0.05) in the treated group,and correlated with the time.Conclusion:Intravenous administration of MSCs after traumatic brain injury increases the expression of growth factors(NGF,BDNF),which possibly improves the recovery of these rats.