皮肌炎
医学
粘膜皮肤区
间质性肺病
皮肤病科
全身性疾病
黑色素瘤
肌炎
病理
疾病
内科学
肺
癌症研究
作者
Drew J.B. Kurtzman,Ruth Ann Vleugels
标识
DOI:10.1016/j.jaad.2017.12.010
摘要
Melanoma differentiation-associated gene 5 (MDA5) is a recently described autoantigen target in a subset of patients with dermatomyositis. Anti-MDA5 dermatomyositis is characterized by a unique mucocutaneous and systemic phenotype that includes cutaneous and oral ulceration, painful palmar papules, alopecia, panniculitis, arthritis, a lower incidence of myositis, and, importantly, an elevated risk of interstitial lung disease with a potentially fatal course. Because the clinical features can differ substantially from those typically observed in cutaneous dermatomyositis, the diagnosis is often overlooked, which might negatively affect patient outcomes. This review aims to familiarize the clinician with the distinctive clinical features of anti-MDA5 dermatomyositis in order to enhance its recognition and to facilitate an appropriate screening and management strategy.
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